Lipase, Liquid

Sustine® 121

Sustine® 121 is a 1,3 liquid lipase that works well with stereoselective hydrolysis and desymmetrization of esters.

Sustine® 121 is already being applied in the following commercial active pharmaceutical ingredients (APIs):

  • Pregabalin

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Details Safe handling

IMPORTANT INFORMATION
Novozymes does not promote or support the use of enzymes as Active Pharmaceutical Ingredients (APIs) or excipients. Novozymes enzymes are industrial bulk products and are not produced according to pharmaceutical standards. Novozymes does not analyze all impurities and/or carry over in the enzyme product. If enzymes are used as process aids, it is the responsibility of the API or excipient manufacturer to assure that the enzymes are suitable for the intended use, including but not limited to evaluation of purity and absence of carry over in final API or excipient product.

This product contains enzymes. While enzymes are safe to use in consumer applications, they need correct handling in working environments to ensure workers’ safety.

Indeed, repeated inhalation of enzyme dust or aerosols resulting from improper handling may induce sensitization and may cause allergic type 1 reactions in sensitized individuals.

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Please follow the precautionary handling recommendations below:

  • Avoid breathing dust/fume/gas/mist/vapors/spray
  • Avoid contact with eyes, skin, or clothing
  • In case of inadequate ventilation wear respiratory protection
  • IF INHALED: Remove person to fresh air and keep comfortable for breathing
  • If experiencing respiratory symptoms: Call a POISON CENTER or a doctor
  • Store in a dry place. Store in a closed container
  • Dispose of contents/containers in accordance with local regulations

 

For more safety information, please watch the entire series of safety videos.

FAQ

Can this product be used in both aqueous and organic solvent processes?

Sustine® 121 works well in aqueous mediums, as well as in a wide range of organic solvents.

Does this product work with low-water content?

Sustine® 121 works well in low-water content.

How do I separate the enzyme from the product after reaction use?

Sustine® 121 is a water-soluble biocatalyst, where 2-3 aqueous extractions will remove all enzyme content.

All our products for biocatalysis

Find the right solution for you in our global portfolio, shown below. To find out more about products available in your region, get in touch with your local Novozymes representative.


Our enzymes are not compliant with pharmaceutical manufacturing standards. They should not be used as APIs or excipients.  

Mode of action
Physical form (recyclability)
Optimal usage conditions - pH, temperature
Commercial applications
Stereoselective hydrolysis of esters, transesterification, and esterification of acids, and acylation of amines.
Immobilized granulate (Yes)
5-9, 30-60°C
APIs:
- Molnupiravir
- Trandolapril
- Amino hydroxypiperidine derivatives
- Pimecrolimus
Agro intermediates
- S-metolachlor and S-dimethenamid – Herbicide intermediate (S)-MOIPA
Stereoselective hydrolysis of esters, trans-esterification, and esterification of acids.
Liquid (No)
5-9, 30-60°C
APIs:
- Pregabalin
- Crizotinib
- 1,4-Dihydropyridines (1,4-DHPs)
- Pimecrolimus
- Thiamphenicol
- Quinolone derivatives
Stereoselective hydrolysis and desymmetrization of esters.
Immobilized granulate (Yes)
6-8, 50-75°C
APIs and their intermediates:
- Pregabalin/- Metronidazole, nimorazole and benznidazole/- Sugar-containing coumarins like warfarin, armillarisin and novobiocin
- Nucleoside analogues of uridine, such as azidothymidine, doxifluridine and telbivudine
Stereoselective hydrolysis and desymmetrization of esters.
Liquid (No)
6-8, 50-75°C
APIs:
- Pregabalin
Stereoselective hydrolysis of esters and transesterification.
Immobilized granulate (Yes)
7-10, 30-50°C
APIs and their intermediates:
- Vitamin E acetate /- Benzyl cinnamate
Stereoselective hydrolysis of esters and transesterification.
Liquid (No)
7-10, 30-50°C
Glycerides/polyols esters, regioselective hydrolysis and esterification.
Liquid (No)
7-10, 30-70°C
APIs and their intermediates:
- Temsirolimus
Sustine® 110 IM
More
Mode of action Stereoselective hydrolysis of esters, transesterification, and esterification of acids, and acylation of amines.
Physical form (recyclability) Immobilized granulate (Yes)
Optimal usage conditions - pH, temperature 5-9, 30-60°C
Commercial applications APIs:
- Molnupiravir
- Trandolapril
- Amino hydroxypiperidine derivatives
- Pimecrolimus
Agro intermediates
- S-metolachlor and S-dimethenamid – Herbicide intermediate (S)-MOIPA
Sustine® 111
More
Mode of action Stereoselective hydrolysis of esters, trans-esterification, and esterification of acids.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 5-9, 30-60°C
Commercial applications APIs:
- Pregabalin
- Crizotinib
- 1,4-Dihydropyridines (1,4-DHPs)
- Pimecrolimus
- Thiamphenicol
- Quinolone derivatives
Sustine® 120 IM
More
Mode of action Stereoselective hydrolysis and desymmetrization of esters.
Physical form (recyclability) Immobilized granulate (Yes)
Optimal usage conditions - pH, temperature 6-8, 50-75°C
Commercial applications APIs and their intermediates:
- Pregabalin/- Metronidazole, nimorazole and benznidazole/- Sugar-containing coumarins like warfarin, armillarisin and novobiocin
- Nucleoside analogues of uridine, such as azidothymidine, doxifluridine and telbivudine
Sustine® 121
More
Mode of action Stereoselective hydrolysis and desymmetrization of esters.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 6-8, 50-75°C
Commercial applications APIs:
- Pregabalin
Sustine® 130 IM
More
Mode of action Stereoselective hydrolysis of esters and transesterification.
Physical form (recyclability) Immobilized granulate (Yes)
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications APIs and their intermediates:
- Vitamin E acetate /- Benzyl cinnamate
Sustine® 131
More
Mode of action Stereoselective hydrolysis of esters and transesterification.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications
Sustine® 140
More
Mode of action Glycerides/polyols esters, regioselective hydrolysis and esterification.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 7-10, 30-70°C
Commercial applications APIs and their intermediates:
- Temsirolimus
Mode of action
Physical form (recyclability)
Optimal usage conditions - pH, temperature
Commercial applications
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