Protease, Liquid

Sustine® 220

Sustine® 220 is a liquid protease that works well with stereoselective hydrolysis of amino esters, selective esters and amides.

Sustine® 220 is already being applied in a number of commercial active pharmaceutical ingredients (APIs) and their intermediates, such as: 

  • Abacavir 
  • Bictegravir
  • Peramivir
  • Vince Lactam (intermediate)

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Details Safe handling

IMPORTANT INFORMATION
Novozymes does not promote or support the use of enzymes as Active Pharmaceutical Ingredients (APIs) or excipients. Novozymes enzymes are industrial bulk products and are not produced according to pharmaceutical standards. Novozymes does not analyze all impurities and/or carry over in the enzyme product. If enzymes are used as process aids, it is the responsibility of the API or excipient manufacturer to assure that the enzymes are suitable for the intended use, including but not limited to evaluation of purity and absence of carry over in final API or excipient product.

This product contains enzymes. While enzymes are safe to use in consumer applications, they need correct handling in working environments to ensure workers’ safety.

Indeed, repeated inhalation of enzyme dust or aerosols resulting from improper handling may induce sensitization and may cause allergic type 1 reactions in sensitized individuals.

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Please follow the precautionary handling recommendations below:

  • Avoid breathing dust/fume/gas/mist/vapors/spray
  • Avoid contact with eyes, skin, or clothing
  • In case of inadequate ventilation wear respiratory protection
  • IF INHALED: Remove person to fresh air and keep comfortable for breathing
  • If experiencing respiratory symptoms: Call a POISON CENTER or a doctor
  • Store in a dry place. Store in a closed container
  • Dispose of contents/containers in accordance with local regulations

 

For more safety information, please watch the entire series of safety videos.

FAQ

Can this product be used in both aqueous and organic solvent processes?

Sustine® 220 works well in aqueous mediums, as well as in a wide range of organic solvents.

Can this product be used for amide bond hydrolysis?

Sustine® 220 can perform selective hydrolysis of selective amides and peptides to corresponding acids.

How do I separate the enzyme from the product after reaction use?

Sustine® 220 is a water-soluble biocatalyst and 2-3 aqueous extractions will remove all enzyme content.

All our products for biocatalysis

Find the right solution for you in our global portfolio, shown below. To find out more about products available in your region, get in touch with your local Novozymes representative.


Our enzymes are not compliant with pharmaceutical manufacturing standards. They should not be used as APIs or excipients.  

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