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Protease, Liquid

Sustine® 250

Sustine® 250 is a liquid protease that works well with neutral pH for hydrolysis of selective amides and internal peptide bonds

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Details Safe handling

IMPORTANT INFORMATION
Novozymes does not promote or support the use of enzymes as Active Pharmaceutical Ingredients (APIs) or excipients. Novozymes enzymes are industrial bulk products and are not produced according to pharmaceutical standards. Novozymes does not analyze all impurities and/or carry over in the enzyme product. If enzymes are used as process aids, it is the responsibility of the API or excipient manufacturer to assure that the enzymes are suitable for the intended use, including but not limited to evaluation of purity and absence of carry over in final API or excipient product.

This product contains enzymes. While enzymes are safe to use in consumer applications, they need correct handling in working environments to ensure workers’ safety.

Indeed, repeated inhalation of enzyme dust or aerosols resulting from improper handling may induce sensitization and may cause allergic type 1 reactions in sensitized individuals.

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Please follow the precautionary handling recommendations below:

  • Avoid breathing dust/fume/gas/mist/vapors/spray
  • Avoid contact with eyes, skin, or clothing
  • In case of inadequate ventilation wear respiratory protection
  • IF INHALED: Remove person to fresh air and keep comfortable for breathing
  • If experiencing respiratory symptoms: Call a POISON CENTER or a doctor
  • Store in a dry place. Store in a closed container
  • Dispose of contents/containers in accordance with local regulations

 

For more safety information, please watch the entire series of safety videos.

FAQ

Can this product be used in both aqueous and organic solvent processes?

Sustine® 250 works well in aqueous mediums, as well as in a wide range of organic solvents.
Can this product be used for amide bond hydrolysis?

Sustine® 250 can perform selective hydrolysis of selective amides and peptides to corresponding acids.
How do I separate the enzyme from the product after reaction use?

Sustine® 250 is a water-soluble biocatalyst and 2-3 aqueous extractions will remove all enzyme content

All our products for biocatalysis

Find the right solution for you in our global portfolio, shown below. To find out more about products available in your region, get in touch with your local Novozymes representative.


Our enzymes are not compliant with pharmaceutical manufacturing standards. They should not be used as APIs or excipients.  

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Sustine® 240
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Sustine® 250
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Type and mode of action
Hydrolysis action and specificity
Physical form
Optimal usage conditions - pH, temperature
Commercial applications
Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Aggressive and broad
Liquid
7-10, 30-50°C
Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Aggressive and broad
Liquid
7-10, 30-50°C
Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Aggressive and broad
Liquid
8-10, 30-70 °C
APIs and their intermediates:
- Abacavir
- Bictegravir
- Peramivir
- Vince Lactam (intermediate)
Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Aggressive and broad
Liquid
8-10, 30-70 °C
APIs and their intermediates:
- Brivaracetam
Exopeptidase that liberates amino acids by N-terminal peptide bonds
Aggressive and broad
Liquid
6-8, 45-60 °C
Metallo endopeptidase that performs hydrolysis of internal peptide bonds
Mild and specific
Liquid
7, 40-50 °C
Sustine® 210
More
Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications
Sustine® 211
More
Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications
Sustine® 220
More
Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 8-10, 30-70 °C
Commercial applications APIs and their intermediates:
- Abacavir
- Bictegravir
- Peramivir
- Vince Lactam (intermediate)
Sustine® 230
More
Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 8-10, 30-70 °C
Commercial applications APIs and their intermediates:
- Brivaracetam
Sustine® 240
More
Type and mode of action Exopeptidase that liberates amino acids by N-terminal peptide bonds
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 6-8, 45-60 °C
Commercial applications
Sustine® 250
More
Type and mode of action Metallo endopeptidase that performs hydrolysis of internal peptide bonds
Hydrolysis action and specificity Mild and specific
Physical form Liquid
Optimal usage conditions - pH, temperature 7, 40-50 °C
Commercial applications
Type and mode of action
Hydrolysis action and specificity
Physical form
Optimal usage conditions - pH, temperature
Commercial applications
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