Substitute your chemical catalysts with lipases from Novozymes

With impressive substrate selectivity and fast reaction rates, lipases are excellent catalysts offering both a sustainable and cost-efficient alternative in your manufacturing.

 

Future-proof your products with green chemistry

Future-proof your products with green chemistry

Conventional fine chemicals often suffer from a number of unsustainable traits, not least their petrochemical origin, scarce supply, and the fact that they can be pollutants that create waste.

At the same time companies need to demonstrate more sustainable manufacturing processes with a reduced environmental impact.

So how can you meet the growing demand for pharmaceuticals with cost-effective fine chemicals that leave no impact on our planet, its people, and animals?

Achieve more with lipases

Lipases are used in many industrial applications where the chemical transformations include enantioselective resolution of esters and amides.

Lipases catalyze the hydrolysis of triacylglycerol to different glycerol derivatives and free fatty acids. They also show diversified specificity for substrates and reactions under anhydrous conditions to synthesize new molecules by esterification, alcoholysis, transesterification and acylation.

Biocatalysis with lipases deliver cost savings, greater sustainability, and better productivity. You can also achieve higher-quality active pharmaceutical ingredients (APIs) and intermediates.

Faster reaction rates

Milder reaction conditions

Impressive reaction specificity with no side products

Get started on your biocatalysis exploration today with a lipase kit from Novozymes

Get started on your biocatalysis exploration today with a lipase kit from Novozymes

Increase your screening hit rate for the right catalyst with a biocatalysis toolbox from Novozymes.

Oftentimes, it is difficult to determine up front which enzyme would work best for a certain application. Why not try a series of our hand-picked enzyme strains to boost your biocatalysis efforts?

Order now and get a discounted price, and a free expert consultation. Limited time offer only.

Lipase application areas

Lipases are used in several industrial applications where the chemical transformations include enantioselective resolution of esters and amides, and other general transformations such as:

  • Acylation of alcohols and amines to form esters and amides
  • Mild hydrolysis or acylation of sensitive substrates
  • Kinetic resolution by transesterification of racemic acids and alcohols
  • Kinetic resolution by hydrolysis of racemic esters
  • Desymmetrization of diesters

Examples of commercial applications, where lipases are being deployed as catalysts are illustrated below. 

 

Lipases

 

Our lipase solutions

Find the right solution for you in our global portfolio, shown below. To find out more about products available in your region, get in touch with your local Novozymes representative.


Enzymes from Novozymes are not compliant with pharmaceutical manufacturing standards. They should not be used as APIs or excipients.  

Mode of action
Physical form (recyclability)
Optimal usage conditions - pH, temperature
Commercial applications
Stereoselective hydrolysis of esters, transesterification, and esterification of acids, and acylation of amines.
Immobilized granulate (Yes)
5-9, 30-60°C
APIs:
- Molnupiravir
- Trandolapril
- Amino hydroxypiperidine derivatives
- Pimecrolimus
Agro intermediates
- S-metolachlor and S-dimethenamid – Herbicide intermediate (S)-MOIPA
Stereoselective hydrolysis of esters, trans-esterification, and esterification of acids.
Liquid (No)
5-9, 30-60°C
APIs:
- Pregabalin
- Crizotinib
- 1,4-Dihydropyridines (1,4-DHPs)
- Pimecrolimus
- Thiamphenicol
- Quinolone derivatives
Stereoselective hydrolysis and desymmetrization of esters.
Immobilized granulate (Yes)
6-8, 50-75°C
APIs and their intermediates:
- Pregabalin/- Metronidazole, nimorazole and benznidazole/- Sugar-containing coumarins like warfarin, armillarisin and novobiocin
- Nucleoside analogues of uridine, such as azidothymidine, doxifluridine and telbivudine
Stereoselective hydrolysis and desymmetrization of esters.
Liquid (No)
6-8, 50-75°C
APIs:
- Pregabalin
Stereoselective hydrolysis of esters and transesterification.
Immobilized granulate (Yes)
7-10, 30-50°C
APIs and their intermediates:
- Vitamin E acetate /- Benzyl cinnamate
Stereoselective hydrolysis of esters and transesterification.
Liquid (No)
7-10, 30-50°C
Glycerides/polyols esters, regioselective hydrolysis and esterification.
Liquid (No)
7-10, 30-70°C
APIs and their intermediates:
- Temsirolimus
Sustine® 110 IM
More
Mode of action Stereoselective hydrolysis of esters, transesterification, and esterification of acids, and acylation of amines.
Physical form (recyclability) Immobilized granulate (Yes)
Optimal usage conditions - pH, temperature 5-9, 30-60°C
Commercial applications APIs:
- Molnupiravir
- Trandolapril
- Amino hydroxypiperidine derivatives
- Pimecrolimus
Agro intermediates
- S-metolachlor and S-dimethenamid – Herbicide intermediate (S)-MOIPA
Sustine® 111
More
Mode of action Stereoselective hydrolysis of esters, trans-esterification, and esterification of acids.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 5-9, 30-60°C
Commercial applications APIs:
- Pregabalin
- Crizotinib
- 1,4-Dihydropyridines (1,4-DHPs)
- Pimecrolimus
- Thiamphenicol
- Quinolone derivatives
Sustine® 120 IM
More
Mode of action Stereoselective hydrolysis and desymmetrization of esters.
Physical form (recyclability) Immobilized granulate (Yes)
Optimal usage conditions - pH, temperature 6-8, 50-75°C
Commercial applications APIs and their intermediates:
- Pregabalin/- Metronidazole, nimorazole and benznidazole/- Sugar-containing coumarins like warfarin, armillarisin and novobiocin
- Nucleoside analogues of uridine, such as azidothymidine, doxifluridine and telbivudine
Sustine® 121
More
Mode of action Stereoselective hydrolysis and desymmetrization of esters.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 6-8, 50-75°C
Commercial applications APIs:
- Pregabalin
Sustine® 130 IM
More
Mode of action Stereoselective hydrolysis of esters and transesterification.
Physical form (recyclability) Immobilized granulate (Yes)
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications APIs and their intermediates:
- Vitamin E acetate /- Benzyl cinnamate
Sustine® 131
More
Mode of action Stereoselective hydrolysis of esters and transesterification.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications
Sustine® 140
More
Mode of action Glycerides/polyols esters, regioselective hydrolysis and esterification.
Physical form (recyclability) Liquid (No)
Optimal usage conditions - pH, temperature 7-10, 30-70°C
Commercial applications APIs and their intermediates:
- Temsirolimus
Mode of action
Physical form (recyclability)
Optimal usage conditions - pH, temperature
Commercial applications

Get expert advice on how to get started on your biocatalysis transition

We’re happy to put you in touch with our industry experts for advice on optimizing your process or finding the right solution or sample to meet your needs. Book a no-obligation meeting with our experts today and let them help you to:

  • Identify the right products or product class for your biocatalysis applications
  • Get technical support related to screening and selection of relevant enzyme samples to be tested in new experimental applications
  • Demonstrate the financial and environmental benefits of transitioning from chemicals to biocatalysis

Novozymes is the world leader in biological solutions

Novozymes is the world leader in biological solutions

With the world’s largest and most diverse collection of enzyme strains, coupled with a global, robust and reliable supply,  Novozymes is here to help you unlock the full potential of your biocatalysis route and make your manufacturing processes more sustainable.

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