Boost your reaction performance with proteases from Novozymes

Benefit from a diverse range of best-in-class proteases offering both broad and aggressive hydrolysis, as well as more specific substrate proteolysis.

 

Future-proof your products with green chemistry

Future-proof your products with green chemistry

Conventional fine chemicals often suffer from a number of unsustainable traits, not least their petrochemical origin, scarce supply, and the fact that they can be pollutants that create waste.

At the same time companies need to demonstrate more sustainable manufacturing processes with a reduced environmental impact.

So how can you meet the growing demand for pharmaceuticals with cost-effective fine chemicals that leave no impact on our planet, its people, and animals?

Achieve more with proteases

Proteases catalyze proteolysis of polypeptides into smaller polypeptides, oligopeptides and amino acids. They do this by cleaving the peptide bonds through hydrolysis. This helps to catalyze stereoselective hydrolysis of amino esters and selective esters to synthesize new molecules in an environmentally-friendly process. Their unparalleled regio- and enantioselectivity, faster reaction rates and performance in milder reaction conditions make proteases ideal reaction catalysts.

Faster reaction rates

Milder reaction conditions

Remarkable reaction specificity with no side products

Get started on your biocatalysis exploration today with a protease kit from Novozymes

Get started on your biocatalysis exploration today with a protease kit from Novozymes

Increase your screening hit rate for the right catalyst with a biocatalysis toolbox from Novozymes.

Oftentimes, it is difficult to determine up front which enzyme would work best for a certain application. Why not try a series of our hand-picked enzyme strains to boost your biocatalysis efforts?

Order now and get a discounted price, and a free expert consultation. Limited time offer only.

Protease application areas

  • Synthesis of Vince Lactam: A key building block/intermediate for antiretroviral APIs (e.g. Abacavir, Bictegravir, Peramivir, etc.)
  • Stereoselective hydrolysis of chiral intermediate for API (e.g. Brivaracetam ) synthesis
  • Other general stereoselective hydrolysis of amino esters and selective esters

Proteases

Our protease solutions

Find the right solution for you in our global portfolio, shown below. To find out more about products available in your region, get in touch with your local Novozymes representative.


Our enzymes are not compliant with pharmaceutical manufacturing standards. They should not be used as APIs or excipients.  

Sustine® 210
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Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications
Sustine® 211
More
Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 7-10, 30-50°C
Commercial applications
Sustine® 220
More
Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 8-10, 30-70 °C
Commercial applications APIs and their intermediates:
- Abacavir
- Bictegravir
- Peramivir
- Vince Lactam (intermediate)
Sustine® 230
More
Type and mode of action Serine endopeptidase that performs stereoselective hydrolysis of amino esters and selective esters
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 8-10, 30-70 °C
Commercial applications APIs and their intermediates:
- Brivaracetam
Sustine® 240
More
Type and mode of action Exopeptidase that liberates amino acids by N-terminal peptide bonds
Hydrolysis action and specificity Aggressive and broad
Physical form Liquid
Optimal usage conditions - pH, temperature 6-8, 45-60 °C
Commercial applications
Sustine® 250
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Type and mode of action Metallo endopeptidase that performs hydrolysis of internal peptide bonds
Hydrolysis action and specificity Mild and specific
Physical form Liquid
Optimal usage conditions - pH, temperature 7, 40-50 °C
Commercial applications
Type and mode of action
Hydrolysis action and specificity
Physical form
Optimal usage conditions - pH, temperature
Commercial applications

Get expert advice on how to get started on your biocatalysis transition

We’re happy to put you in touch with our industry experts for advice on optimizing your process or finding the right solution or sample to meet your needs. Book a no-obligation meeting with our experts today and let them help you to:

  • Identify the right products or product class for your biocatalysis applications
  • Get technical support related to screening and selection of relevant enzyme samples to be tested in new experimental applications
  • Demonstrate the financial and environmental benefits of transitioning from chemicals to biocatalysis

Novozymes is the world leader in biological solutions

Novozymes is the world leader in biological solutions

With the world’s largest and most diverse collection of enzyme strains, coupled with a global, robust and reliable supply,  Novozymes is here to help you unlock the full potential of your biocatalysis route and make your manufacturing processes more sustainable.

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