Achieve clinical clean with enzymes

The burden of Healthcare Acquired Infections (HAIs) can be reduced by effective cleaning of clinical soils. It's time to take a closer look at the role enzymes can play in medical detergent.

Why enzymatics?

Why enzymatics?

HAIs place a significant burden on healthcare systems around the world. In the US alone, the Centers for Disease Control and Prevention estimate the overall annual direct financial costs of HAIs to hospitals at between $28bn and $45bn, and the cost in lives at around 72k per year. Effective cleaning is a critical part of preventing HAIs.

Enzymes are an important part of the medical cleaning process, from presoak to washing. If medical instruments are not cleaned, they can't be properly sterilized. The right enzymes in the right dosage can help eliminate difficult soils and reduce HAI risk.

Enzymatic medical detergents:

  • Rapidly break down organic, clinical soils rich in protein and fat
  • Are made to perform well in a wide range of cleaning environments
  • Are gentler on delicate instruments & medical devices
  • Improve cleaning efficiency supported by studies performed on clinically relevant soils
  • Are less dangerous for technicians to be exposed to daily
  • Provide natural and safe cleaning power

How enzymes work

How enzymes work

Enzymes are tiny powerhouses that speed up chemical reactions. Renewable and biodegradable, they are a more sustainable choice for cleaners than harsh chemicals. Enzymes in cleaning solutions bind with soils and break them down into smaller pieces, making them easier to remove. 

Novozymes Everisenzymes specifically target the various types of organic matter commonly found in clinical soils. Proteases target protein-rich matter like blood, while lipases target fatty matter like adipose tissue. Amylases and cellulases target the starch and cellulosic polymers found in waste such as feces.

Enzymes work in synergy with surfactants to rapidly breakdown organic soils at the molecular level making them easier to remove leaving only a clean surface behind - a clean that we call clinically clean. Detergents formulated only with surfactant lack this powerful synergistic cleaning effect providing only a superficial clean.

Though enzymes have long been used in medical device cleaning, advancements in enzymatic technology have led to new, improved molecules that deliver even more effective cleaning of clinical soils. 


Are your instruments as clean as they could be?

The average medical detergent only removes 51% of organic soil. Download our study to learn how you can achieve clinical clean for the best patient outcomes with the right dose and type of enzymes.

  • The impacts of inadequate cleaning
  • Why the amount and type of enzyme matters
  • The difference with fluorescence analysis



Everis™ helps detergent manufacturers

Achieve clinical clean

Enzyme performance can be optimized with the right enzyme, at proper dosage and cleaning parameters. Everis™ enzymes are optimized to deliver a deep, thorough clean – even in hard-to-reach spots like crevices, joints and cracks that are invisible to the naked eye.

Go beyond industry standards

Every batch of Everis™ enzymes delivers the quality, color, and consistency the healthcare industry requires. Everis™ is designed to work with healthcare- specific temperature and pH ranges.

Create innovative products

Everis™ enzymes are innovative healthcare-grade enzymes fine-tuned and optimized. They enable detergents to deliver true clinical clean and can help brands stand out from the competition.

Superior cleaning even under tough conditions

Superior cleaning even under tough conditions

Everis™ is targeted for medical device cleaning function under a variety of conditions, including high alkalinity. Watch how they easily remove soil. Our latest advances in protease technology can help set your detergent apart from your competitors.

Let's talk

Get in touch with us to explore how enzymes can help differentiate your brand.

Enzymes for enhanced safety 

Enzymes for enhanced safety 

In healthcare settings, clinical soils are commonly found embedded deeply into hinges, textured surfaces and hard-to-reach parts of reusable medical devices. Enzymatic detergents that specifically target clinical soils have been in use for decades and a number of studies have investigated their performance in medical device cleaning. One demonstrated their improved performance in comparison with non-enzymatics, while another demonstrated that they have an advantage over alkaline cleaners.

They can enhance cleaning and safety in multiple healthcare applications; from bedside pre-cleaning to automatic washing in a hospital’s sterile processing department.

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Frequently Asked Questions

What are enzymes and why are they used in medical cleaning?

Enzymes are biomolecules that speed up chemical processes such as cleaning. In medical device reprocessing, enzymes work in combination with detergents to break down organic matter commonly found in clinical soils, making them easier to remove. They are gentle on delicate medical instruments and devices and are readily biodegradable. Their function can be optimized to ensure the best possible cleaning by leveraging key factors such as the right enzyme for the instruments intended to be used on, enzyme dose, and the time instructed.

What are the types of enzymes used in medical detergents?

Two main enzyme classes have been used to clean medical devices: protease and lipase. Proteases are designed to break down protein-rich soils like blood, while lipases target fatty soils like adipose tissue. Amylases and Cellulases are also commonly used in this application to breakdown carbohydrate-based soils that may be associated with feces and residual organic films commonly found in endoscopes. Combining multiple enzymes with a properly formulated detergent can help break down a variety of human soils and waste, and improve cleaning outcomes.

How do enzymes function?

Enzymes are an important component of a good cleaning detergent. They work in synergy with surfactants, or wetting agents, by breaking organic soils into smaller pieces, making it easier for the surfactants to remove the soils from the surface of the instrument. By using the right enzymes, enzymatic detergents can break down soils under a wide range of temperatures. And, they can also function at different pH levels, from neutral (or mild) to alkaline (or harsh) conditions.

Will any amount of enzymes will make detergent more effective?

No! To get the full benefit of a medical cleaning detergent, it’s necessary to have a proper dose of enzymes to effectively function under limited time constraints. Without the proper amount of enzymes included, the medical detergent may not be as effective as needed for optimal cleaning. When choosing detergent for your healthcare facility, make sure you inquire about enzyme dosage included in your product used.

Are enzymes better for the environment?

Many studies have shown that enzymes are easier on the planet than harsh chemicals. These processing aids that are found in nature are completely biodegradable, making them safe and effective for your instruments as well as the water stream that the detergent will eventually return to, which may help you in reaching your sustainability goals. So, when choosing a detergent, look for gentle formulas containing a high enzyme dosage for both improved performance and a reduced environmental impact.

Please note: Novozymes' customers can download guidelines
on safe handling of enzymes from Novozymes Market.