The endoscope challenge
Learn why multi-enzymatic detergents deliver enhanced, targeted cleaning power on endoscope organic films.
In the US alone, the Centers for Disease Control and Prevention estimate the overall annual direct financial costs of HAIs to hospitals at between $28bn and $45bn, and the cost in lives at around 72,000 per year. HAIs can lead to longer hospital stays, long-term disability and increased costs for patients, their families and healthcare providers.
It is proven that enzymatic detergents can enhance cleaning and patient safety in multiple healthcare applications, from manual soaking to automatic washing in a hospital’s sterile processing department.
Designed to replicate real conditions and study action on real soils
The study replicated endoscope cleaning challenges by testing different detergents’ ability to clean organic soils left by two pathogens that can cause HAIs - Klebsiella pneumoniae and Pseudomonas aeruginosa. Both organisms are common isolates found in dirty medical instruments. By using real soils, the experiments came closer to real-life conditions faced by hospital sterile processing departments.
While the direct count results were not as consistent with respect to the top performers as the fluorescence results, detergents E and G again demonstrated some of the best results. Treatment with these two detergents compared to the detergent only control showed more chemically-killed bacteria had been washed from the system leaving behind fewer chemically-killed bacteria in the tubing. Detergents D and F also performed well, and although Detergent C was not a top performer, it still performed better than the control detergent without enzymes. Once again, the detergent containing only a protease did not perform as well as the other enzymatics, further indicating that single enzyme solutions are not as effective as multi-enzymatic ones at cleaning complex organic soils. The results of the study demonstrated a reduction of some soils with enzymes, and positive trends in improving the ease of cleaning the teflon surface by loosening the glue-like properties of the organic residue. This was particularly clear in the experiments around sticky DNA soil where detergents C, E and G consistently stood out. All three detergents contain Everis™ Next, which is a newly released enzymatic innovation designed for complex medical soils.
Commenting on the study, Novozymes Senior Scientist John Howell says, “Adjusting some of these parameters may have further improved outcomes. For example, the study focused on the enzyme and detergent content and did not look at the effects of the age of the organic film, mechanical action (e.g., flushing while cleaning), temperature, dosing or time.”
Endoscope cleaning requires broad-spectrum enzymatic detergents
Getting an endoscope clean enough for subsequent effective high-level disinfection requires a broad-spectrum- approach – with the right enzyme content. Today’s average medical detergents typically use 1- 1.5 enzymes. To advance cleaning, especially with endoscopes, we must use more than two enzymes from different classes. The study also indicates that the advanced enzymes tested, Novozymes Everis™ Next and Everis™ Guard, can deliver robust performance in combination with other enzymes.
In recent years, the composition of detergents has changed with greater dosing of enzymes and a wider range of enzymes. This has given many sterile processing departments the cleaning performance they need. Now this study establishes a good baseline and proof of concept for the use of multienzymes in tackling complex soils in medical cleaning. However, more studies are required to further understand the role of enzymes in cleaning.
If you are interested in hearing more about this study or partnering for future studies, contact us below.
*This information was provided under a Montana State University Testing Services Agreement and is not intended to endorse or recommend any product or service.